HFD-induced hepatic lipid accumulation and inflammation are decreased in Factor D deficient mouse

HFD-induced hepatic lipid accumulation and inflammation are decreased in Factor D deficient mouse

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Abstract Excessive intake of fat causes accumulation of fat in liver, leading to non-alcoholic fatty liver disease (NAFLD).High-fat diet (HFD) upregulates the expression of Factor D, a complement pathway component, in the liver of mice.However, the functions of Factor D in liver are not well known.

Therefore, the current study investigated the relationship between Factor D and hepatic lipid accumulation Oven Door Hinge Support using CRISPR/Cas9-mediated Factor D knockout (FD-KO) mice.Factor Tumbler D deficiency downregulated expression of genes related to fatty acid uptake and de novo lipogenesis in the liver.Furthermore, Factor D deficiency reduced the expression of inflammatory factors (Tnf and Ccl2) and fibrosis markers and decreased accumulation of F4/80-positive macrophages.

These data suggest that the Factor D deficiency improved hepatic lipid accumulation and hepatic inflammation in HFD-fed mice.